A Salmonella vaccine designed to fight the Enteritidis serotype with decreased susceptibility to ciprofloxacin (DSC) performed well in a research trial at the USDA Agricultural Research Service’s (ARS) National Animal Disease Center (NADC), in Ames, Iowa.
The live, attenuated USDA Salmonella vaccine significantly reduced intestinal colonization and movement of DSC Enteritidis to the spleen in broiler chickens. It also prevented DSC Enteritidis dissemination to the bone marrow.
“Vaccination can reduce Salmonella in animals raised for food, and that is going to decrease transmission to vulnerable animals and reduce environmental contamination,” reported Shawn Bearson, PhD, USDA ARS research microbiologist, at the 2025 International Poultry Scientific Forum.